Simple models of genomic variation in human SNP density
نویسندگان
چکیده
منابع مشابه
Incorporating spatial variation in density enhances the stability of simple population dynamics models.
Simple discrete time models of population growth admit a wide variety of dynamic behaviors, including population cycles and chaos. Yet studies of natural and laboratory populations typically reveal their dynamics to be relatively stable. Many explanations for the apparent rarity of unstable or chaotic behavior in real populations have been developed, including the possible stabilizing roles of ...
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We have surveyed and summarized several aspects of DNA variability among humans. The variation described is the result of mutation followed by a combination of drift, migration and selection bringing the frequencies high enough to be observed. This paper describes what we have learned about how DNA variability differs among genes and populations. We sequenced functional regions of a set of 3950...
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Recently there has been considerable interest in the use of single nucleotide polymorphisms (SNP) for understanding the genetics of complex human diseases. The reasons are multiple. Firstly, SNPs are much more abundant than microsatellite polymorphisms (about once every 500-1000 base pairs 1) and hence are potentially more powerful in detecting linkage disequilibrium around disease loci. Second...
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Rapid advances in DNA sequencing and genotyping technologies are beginning to reveal the scope and pattern of human genomic variation. Although single nucleotide polymorphisms (SNPs) have been intensively studied, the extent and form of variation at other types of molecular variants remain poorly understood. Polymorphism at the most variable loci in the human genome, microsatellites, has rarely...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2007
ISSN: 1471-2164
DOI: 10.1186/1471-2164-8-146